• Also known as Weil’s disease; Uncommon (~1 in 1 million; although most common zoonosis in the world)
  • Commonly seen in sewage workers; farmers; vets or abattoir workers
  • Caused by the spirochete organism Leptospira interrogans
  • Classically spread by rat urine but can be spread via contaminated water/soil from contact from infected animals


  • Fever
  • Flu-like symptoms e.g. myalgia; arthralgia; headache; sore throat; nausea/vomiting
  • Renal failure (50%)
  • Purpura, petechiae, epistaxis, minor haemoptysis
  • Jaundice
  • Subconjunctival haemorrhage
  • Headache and meningism (meningeal infection)


  • Generic
    • LFT- deranged (increase bilirubin and AST/ALT)
    • FBC- thrombocytopenia, leukocytosis, anaemia
    • U&E- AKI; raised CK
    • Urinalysis- proteinuria
    • CXR- patchy alveolar haemorrhage
  • Diagnosis
    • Serology


  • High dose doxycycline or benzylpenicillin (for more severe cases)



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