Leptospirosis

Background

  • Also known as Weil’s disease; Uncommon (~1 in 1 million; although most common zoonosis in the world)
  • Commonly seen in sewage workers; farmers; vets or abattoir workers
  • Caused by the spirochete organism Leptospira interrogans
  • Classically spread by rat urine but can be spread via contaminated water/soil from contact from infected animals

Presentation

  • Fever
  • Flu-like symptoms e.g. myalgia; arthralgia; headache; sore throat; nausea/vomiting
  • Renal failure (50%)
  • Purpura, petechiae, epistaxis, minor haemoptysis
  • Jaundice
  • Subconjunctival haemorrhage
  • Headache and meningism (meningeal infection)

Investigations

  • Generic
    • LFT- deranged (increase bilirubin and AST/ALT)
    • FBC- thrombocytopenia, leukocytosis, anaemia
    • U&E- AKI; raised CK
    • Urinalysis- proteinuria
    • CXR- patchy alveolar haemorrhage
  • Diagnosis
    • Serology

Management

  • High dose doxycycline or benzylpenicillin (for more severe cases)

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: