Dermatitis Herpetiformis


  • Dermatitis herpetiformis is an uncommon, symmetrical vesiculo-bullous disorder which mainly affects the extensor surfaces.
  • Usually presents in 3rd/4th decade and more common in men (2:1).
  • Most cases are associated with Coeliac disease (jejunal villous atrophy) (1 in 10 will also have a family history)
    • NB symptoms of this may be mild or even absent
    • Anti-endomysial antibodies are usually present and skin biopsy often shows IgA deposition along the dermal papillae


  • Blisters are rarely found intact (usually excoriated) commonly on the knees, elbows, buttock, scalp and, occasionally, trunk
  • Extremely itchy
  • Skin may be normal or erythematous


  • As for coeliac i.e. antiendomysial antibody, gliadin antibody
    • May also have a mild anaemia (may be micro-, macro-, or normo-cytic)
  • Immunofluorescence (IgA deposition)


  • Gluten free diet
  • Dapsone (antimicrobial cream)
    • Or ultrapotent steroids

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